Vanity Fair | "Cary in the Sky with Diamonds" — Before Timothy Leary and the Beatles, LSD was largely unknown and unregulated. But in the 1950s, as many as 100 Hollywood luminaries—Cary Grant and Esther Williams among them—began taking the drug as part of psychotherapy. By Cari Beauchamp and Judy Balaban

There is no question that, at least for a period of time, LSD truly transformed Cary Grant. “When I first started under LSD, I found myself turning and turning on the couch,” he later told a friendly reporter. “I said to the doctor, ‘Why am I turning around on this sofa?’ and he said ‘Don’t you know why?’ and I said I didn’t have the vaguest idea, but I wondered when it was going to stop. ‘When you stop it,’ he answered. Well, it was like a revelation to me, taking complete responsibility for one’s own actions. I thought ‘I’m unscrewing myself.’ That’s why people use the phrase, ‘all screwed up.’ ”

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    no question that,...truly transformed Cary Grant. “When I first started

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